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15 of the Best Drugstore Acne Treatments To Ward Off Breakouts

Treating acne doesn’t always require a prescription. Some of the best drugstore acne products are cost-efficient and get the job done. Dermatologists’ top tip is to look at the ingredients the product contains. All three derms we chatted with agreed that retinol, benzoyl peroxide, and salicylic acid make the product go from “good” to “great.”

01of 15Differin Acne Treatment Gel

“Retinoids are the absolute backbone of an acne treatment,” says Levin. “They de-clog pores by normalizing skin cell turnover to prevent dead skin cells from clogging pores, but they also act as an anti-inflammatory.”

02of 15Clean & Clear Advantage Acne Spot Treatment

“Salicylic acid is a common over-the-counter product that breaks up dead skin cells to clear out blackheads,” says Levin. “More importantly, salicylic acid is a lipid-loving acid and, therefore, concentrates in pores, since pores are connected to our oil glands.”

03of 15Cetaphil DermaControl Oil Control Moisturizer SPF 30

Less is more with acne-fighting ingredients. Bae cautions against using them altogether, as they all contribute to drying out the skin. “Alcohol-based products like astringents can further exacerbate dry skin as a result of treating with these ingredients,” she says. “It’s so important to ensure daily sunscreen use and to moisturize.” This Cetaphil moisturizer fights oil while providing UV protection.

04of 15Thayers Witch Hazel Alcohol-Free Toner – Rose Petal

Toner can be a godsend for those who regularly experience breakouts, but many formulas are very harsh and packed with a few too many acne-fighting ingredients. We’re big fans of this alcohol-free witch hazel, which has aloe and rose petal meant to soothe while also controlling oil.

05of 15Cetaphil DermaControl Oil Removing Foam Wash

“The most important thing to remember is acneic skin is damaged skin. A harsh cleanser will cause more harm than good,” says Friedman. “Mild cleansers that are pH balanced and do not contain surfactants (the part of soap that binds to dirt/fat on the skin) are ideal. Some foaming cleansers, like Cetaphil DermaControl, are mild and good for oily skin.”

06of 15Differin Daily Deep Cleanser

“An acne-free, oil-free cleanser with benzoyl peroxide and glycolic acid [is my favorite] because the lower percentage benzoyl peroxide is gentle yet effective to treat acne, and the added glycolic acid helps exfoliate the skin, like the Differin Daily Deep Cleanser, which contains 5 percent of benzoyl peroxide,” says Bae. Friedman adds, “when it comes to benzoyl peroxide, less is more.”

07of 15Burt’s Bees Herbal Complexion Stick

If you’re sensitive to the popularly-touted, anti-acne ingredients mentioned in this article, like benzoyl peroxide and salicylic acid, try this tea tree oil blemish stick from Burt’s Bees. The combination of astringent tea tree and juniper oils, exfoliating willow bark, and soothing calendula come in a convenient roll-on stick form for easy reapplication.

08of 15Glytone Mild Gel Cleanser

“My favorite gentle acne cleansers are those with glycolic acid,” says Levin. “Many of my patients who are dealing with female adult acne also have an intolerance to the traditional acne medications that they used to be able to tolerate as a teenager, such as benzoyl peroxide and salicylic acid. Using a mild exfoliating cleanser with glycolic acid chemically exfoliates the skin with a small percentage of glycolic acid.”

09of 15Avène Cleanance Mattifying Emulsion

For sensitive skin, Bae likes this product from Avène. It has a mattifying formula with a velvet-like texture that helps eliminate blemishes in the gentlest way possible.

10of 15Prosacea Medicated Rosacea Gel

KEY INGREDIENTS: Sulfur is a natural element that is an essential component for all living cells. Sulfur-based products tend to work best for mild-to-moderate acne, primarily whiteheads, blackheads, and papules.As a spot treatment, Prosacea’s product “contains sulfur, which is a keratolytic with antibacterial properties,” says Bae. “The product also includes skin soothers like aloe to help moisturize and soothe the skin.”

11of 15L’Oreal Detox & Brighten Clay Mask

For a quick fix, clay masks are a great option. This affordable option contains activated charcoal meant to draw out impurities. It’s a creamy, non-drying formula that can minimize breakouts in a pinch.

12of 15Cover Dot Acne Care Hydrocolloid Waterproof Clear Pimple Absorbing Acne Patch

One of these patches will help heal a pimple faster “because it absorbs the fluid from the pimple; creates a moist environment to allow for faster and improved healing; protects the pimple from you picking and against sunlight, which accelerates healing; and minimizes exposure to UV radiation to minimize hyperpigmentation,” says Levin.

13of 15Neutrogena Hydro Boost Gel-Cream

If your pores are easily clogged, it’s good to have a lightweight moisturizer on hand. We love this hyaluronic acid gel cream from Neutrogena, which is both extremely hydrating and non-greasy.

14of 15EB5 Anti-Aging Vitamin C Serum Concentrate

“We are learning that free radicals can also contribute to acne. Therefore, using an antioxidant serum can help combat this cause,” says Bae. “Plus, vitamin C is known to help brighten skin, so it will also help fade those acne marks.”

15of 15Cortizone Maximum Strength Ointment

When breakouts are extremely inflamed, they can be painful. Sometimes, the thought of putting possibly irritating ingredients on already red, itchy, and swollen patches of skin can make you cringe. Have a tube of cortisone ointment on hand to soothe that discomfort and prevent itchiness.

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